ANXA1 and cancer: This evidence is consistent with the study of Luthra and colleagues [28] which showed a significant inverse correlation of miR-196a2 with ANXA1 mRNA levels in 12 cancer cell lines of esophageal, breast and endometrial origin, and that of Pin and his colleagues [14] that demonstrated miR-196a2 regulation of ANXA1 expression in endothelial cells.