Considering the results for the variant encoding p.Arg381Gln in IL23R gene, we noted that Il-23R and Th17 cytokines are down-regulated after successful therapies and there are monoclonal antibodies directed against IL-12/23p40, IL-17A and IL-17RA which are effective in psoriasis [1, 26]. This evidence concerns the gene IL17A and psoriasis.