LHCGR and Autoimmunity: Although they represent only a small fraction of cases, the X chromosome abnormalities (13%), autoimmunity (30 to 40%) and premutation of the fragile mental retardation 1 (FMR1) gene (6%) have been associated with the incidence of POI.(7) Moreover, the literature describes polymorphisms and mutations in several genes related to sporadic form of POI, including the follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR) and inhibin alfa (INHA).(8-14)