It is characterized by the absence of menstruation for a period longer than 4 months (secondary amenorrhea), but can be manifested before menarche, leading to amenorrhea.(1) In 2015, the European Society of Human Reproduction and Embryology guidelines defined as criteria for POI the observation of two measurements of follicle stimulanting hormone (FSH) levels higher than 25IU (international units), performed within a 4-week interval. The gene discussed is BRD2; the disease is amenorrhea.