CD8A and infection: An evaluation of the cytotoxic activity of CD8+ T cells in sub-clinical infections and patients with CL showed that CD8+ T cells in individuals with CL induced apoptosis of more infected monocytes than CD8+ T cells from sub-clinically infected subjects, and the production of granzyme B in CD8+ T cells was higher in individuals with CL than in those with sub-clinical infection (Cardoso et al. 2015).