Interestingly, the large Mo.X.2 region, which is associated with the same PC as Mitf, includes Ap1s2. This gene is a target of the Mitf-regulated miRNA miR-211, and its function has been validated in the context of melanoma (Margue et al., 2013) and osteosclerosis in humans (Saillour et al., 2007). The gene discussed is MITF; the disease is osteosclerosis.