Interestingly, the large Mo.X.2 region, which is associated with the same PC as Mitf, includes Ap1s2. This gene is a target of the Mitf-regulated miRNA miR-211, and its function has been validated in the context of melanoma (Margue et al., 2013) and osteosclerosis in humans (Saillour et al., 2007). This evidence concerns the gene AP1S2 and melanoma.