Activating FLT3 mutations including internal tandem duplication (ITD) as well as tyrosine kinase domain (TKD) mutations and point mutations in exone 12 of NPM1 are reported as frequent mutations in AML in an average young trial population with reported incidences of 33 and 28%, respectively [8], whereas mutations in CEBPA are less frequent [12]. This evidence concerns the gene NPM1 and acute myeloid leukemia.