Similarly, several other genes, including TMEM, COMT, IF4G1E, GRIN2A, GSTP1, TNF-α, COX-2, SLC6A3, ADH1C, rs356219, SREBF1 and SREBF2, HLA-DRB5, BST1, GAK, ACMSD, STK39, MCCC1, SYT1, CCDC62/HIP1R are also involved in development of PD. Here, PTGS2 is linked to Parkinson disease.