Interestingly, several molecular, genetic and biochemical studies evidenced that a mixture of multiple misfolded protein aggregates, such as p-tau, Aβ, and SNCA, are frequently seen in human post-mortem brains of patients who were neuropathologically diagnosed as having mixed dementia with Lewy bodies (DLB) and PD with dementia (PDD) [67]. The gene discussed is SNCA; the disease is dementia.