MAP1LC3A and Parkinson disease: For example, accumulation of autophagy vacuoles [132] and levels of the ALP markers, microtubule-associated protein 1 light chain 3 (LC3) [133] have been reported to increase in the SNpc area of postmortem PD brain and temporal cortex of patients with DLB [134] in comparison to age-matched controls, suggesting dysfunction of autophagy is linked with PD progression.