miR-223 affects different target genes at multiple cancers like Artemin (oesophageal carcinoma) 41, C/EBPβ (leukaemia) 42, E2F1 (leukaemia) 35, EPB41L3 (gastric cancer) 36, Fbxw7/Cdc4 (leukaemia, gastric cancer, oesophageal squamous cell carcinoma) 43,44, FOXO1 (colorectal cancer cells) 45, HSP90B1 (osteosarcoma) 46, IGF1R (HeLa, leukemia and hepatoma cells) 37,47, SEPT6 (prostate cancer) 48, LMO2 (Leukaemia/lymphoma) 42 and NFI-A (Leukaemia/lymphoma) 49. The gene discussed is E2F1; the disease is colorectal cancer.