They are also involved in the expression of over 30 genes that regulate the synthesis and use of cholesterol, fatty acids, triglycerides, and phospholipids (Kojima and Degawa, 2006; Reddy and Rao, 2006; Ahmed and Byrne, 2007).SREBP-1c is directly associated with lipid accumulation in NAFLD (Ahmed and Byrne, 2007; Duvnjak et al., 2007) and stimulates the translation of lipogenic genes such as those coding for FAS, ME, and glucose 6-phosphate dehydrogenase (G6PDH). This evidence concerns the gene MMP12 and metabolic dysfunction-associated steatotic liver disease.