Interestingly, CBL0100 showed a similar inhibitory effect on the wt and ΔκB viruses, suggesting that CB0100 does not require an intact NF-κB site at the 5′ LTR to suppress HIV-1 transcription; which is different from its anti-tumor activity (Gasparian et al., 2011). Here, NFKB1 is linked to neoplasm.