However, while we were unable to detect an alteration to pulmonary function in the Hepc KO mice (for example, we did not find any differences in blood oxygen saturation between Hepc KO and WT mice, data not shown), Neves et al. reported a distinctive phenotype of restrictive lung disease in the Slc40a1C326S mice, in association with decreased total lung capacity and reduced blood oxygen saturation (Neves et al., 2017). Here, HAMP is linked to Restrictive ventilatory defect.