Accordingly, Hepc KO mice (Lesbordes-Brion et al., 2006), as well as Hepc KOliv mice (Zumerle et al., 2014), develop a severe iron overload phenotype with elevated iron levels in the plasma, liver and pancreas, and iron deficiency in macrophages of the spleen and the liver. The gene discussed is HAMP; the disease is Iron deficiency anemia.