Intriguingly, our previous study revealed that plasma levels of IL-1β, IL-6, and TNF-α were positively correlated with AMS severity at 3,700 m, and another recent study revealed that plasma IL-6 levels were positively associated with AMS severity at 4,450 m and 5,129 m (Boos et al., 2016; Song et al., 2016). The gene discussed is IL6; the disease is ablepharon macrostomia syndrome.