The other mTOR complex, mTORC2, shares mLST8 and DEPTOR with mTORC1 and includes unique components: the rapamycin-insensitive companion of mTOR (rictor), mammalian stress-activated map kinase-interacting protein 1 (mSIN1), and the exchange factor found in platelets and leukemia and neuronal tissues (Xpln). The gene discussed is MTOR; the disease is leukemia.