Akin to this, disruption of energy metabolism of cancer (Fu et al., 2015), induction of thermal stress (Dayanc et al., 2013), exposure to pro-oxidants such as hydrogen peroxide (Yamamoto et al., 2001) and reactive oxygen species (Soriani et al., 2014) have been shown to up-regulate the expression of MIC-A/B in cancer. This evidence concerns the gene MICA and cancer.