Accordingly, the authors aim to shed light on vascular conditions (hypertension, hyperlipidemia, hyper-coagulation, and arrhythmia), which represent the systemic pathological state that leads to vascular dementia, unlike AD-based primary pathophysiological processes that directly lead to specific neurodegenerative cellular processes (e.g., producing abnormal levels of tau proteins; Mattsson et al., 2009). This evidence concerns the gene MAPT and Alzheimer disease.