Intratumoral injection of siRNA targeting CHL1 significantly reduces the fold increases in tumor volume at most time points post siRNA transfection (p < 0.05 vs. control siRNA at 3, 5, 7, 10, 11, 12 and 13 day points post 1st siRNA injection; p < 0.01 vs. control siRNA at 4, 6, and 9 day points post the 1st siRNA injection; Figures 9A–C). Here, CHL1 is linked to neoplasm.