Providing an explanation for the axonal degeneration phenotype observed in tauopathies, multiple independent studies documented deficits in AT triggered by pathogenic forms of tau, including oligomeric tau (Higuchi et al., 2005; Gotz et al., 2006; Cox et al., 2016; Swanson et al., 2017). The gene discussed is MAPT; the disease is tauopathy.