Evidence of conjugates that encompass a dual IRAK1/4 kinase inhibitor bound to a Bruton's tyrosine kinase inhibitor resulted in inhibition of NF-κB. In fact, increasing evidence suggests that IRAK inhibitors could be a possible therapy for NF-κB-dependent B cell lymphoproliferative disease Waldenstrom's macroglobulinemia [197, 198]. Here, NFKB1 is linked to Waldenstrom macroglobulinemia.