Many of these factors that are altered in the serum or bone marrow of MM subjects have proinflammatory activity, such as IL-1, IL-6, IL-12, IL-15, IL-16, IL-17, IL-18, IL-22, IL-23, TNF-α, and IFN-γ, while others exert anti-inflammatory effects, such as IL-1Rα, IL-4, IL-10, IL-11, TGF-β1, heat-shock proteins (HSPs), and lipoxin A4. This evidence concerns the gene IL1A and Miyoshi myopathy.