The molecular profiles of AML exosomes isolated from pre-therapy plasma were enriched in leukemia associated antigens (LAAs) and in proteins that mediate immune suppression, such as TGF-β1/LAP, CD39/CD73 ectoenzymes, PD1/PD-L1 or Fas/FasL (Fig. 2a). This evidence concerns the gene TGFB1 and acute myeloid leukemia.