In the MCF-7 network, MYC is a broad domain node and connected to multiple enhancer and super enhancer nodes, one of which harbors rs1121946 SNP that is in high linkage disequilibrium (LD) with index SNP rs11780156 (r2 > 0.7), a known breast-cancer associated variant (Fig. 6b-c). The gene discussed is MYC; the disease is breast cancer.