AR and Alzheimer disease: Although we expected that TRX1 inhibition would reduce AR levels in the CRPC LNAI cells, to correspond with its concomitant negative impact on proliferation and survival, (Figs. 2, 3), surprisingly we found that both shTRX1 and PX-12 treatment led to elevated AR levels, with a more pronounced increase under AD (Fig. 4a; Supplementary Fig. 5a).