Comparison of TRX1 protein levels among AD-responsive LNCaP SB0, early CRPC LNCaP SB5, and an established LNCaP-derived CRPC line LNAI41,42 demonstrates that the two CRPC lines, SB5 and LNAI, do not show an AD-associated decline in TRX1 levels, unlike their parental LNCaP SB0 line (Fig. 1f; Supplementary Fig. 1b). Here, TXN is linked to Alzheimer disease.