Given that our results point to inappropriate AR elevation as a major transducer of PX-12 response, it is encouraging that this effect is selective for CRPC and is not observed in AD-responsive PCa cells (Supplementary Fig. 5b) nor in non-tumorigenic RWPE-1 cells (in which AR levels remained undetectable under a variety of doses and treatment durations). This evidence concerns the gene AR and posterior cortical atrophy.