Several peaks of homozygous deletions point to genes not previously implicated as tumour suppressors, e.g., LEPROTL1, KIAA1551, MIDEAS, MAFTRR, and IGF2BP2. Together with its homologue Leptin Receptor Overlapping Transcript (LEPROT), LEPROTL1 negatively regulates leptin receptor surface expression and thus the response to leptin, a pleiotropic hormone50,51. This evidence concerns the gene LEPR and neoplasm.