Result of Cox multivariate analysis showed that EZH2 rs12670401, EZH2 rs6464926 and clinical staging, mRNA and protein expression of EZH2 and SMYD3, lymph node metastasis, HER2 status, and metastasis situation were independent prognostic factors for survival rate of breast cancer patients. The gene discussed is EZH2; the disease is breast carcinoma.