Multivariate logistic regression analysis was carried out with breast cancer as a dependent variable, and different genotypes (EZH2 rs12670401, EZH2 rs6464926, and SMYD3 VNTR) in the case and control groups and baseline characteristics (age, age of menarche, and menopausal status) as independent variables. This evidence concerns the gene SMYD3 and breast carcinoma.