There was an obvious difference in allele frequency (χ2 =8.286, P=0.004) and genotype frequency (χ2 =8.972, P=0.003) of EZH2 rs6464926, and T allele could increase the susceptibility to breast cancer (OR =1.240, 95% CI: 1.071–1.435, P=0.004). The gene discussed is EZH2; the disease is breast carcinoma.