The association between polymorphisms and breast cancer prognosis was analyzed by Kaplan–Meier survival, and the result showed that the OS of patients with TT genotype was higher than those with TC + CC genotype in EZH2 rs12670401 locus, and the OS of the patients with CC genotype was higher than those with CT + TT genotype in EZH2 rs6464926 locus (both P<0.05); the OS of the patients with 2/2 genotype was higher than those with 2/3 + 3/3 genotype in SMYD3 VNTR locus, but the difference was not statistically significant (P>0.05) (Figure 4). The gene discussed is SMYD3; the disease is breast cancer.