Result of Cox multivariate analysis declared that EZH2 rs12670401 and EZH2 rs6464926 genotypes, mRNA and protein expression of EZH2 and SMYD3, clinical staging, lymph node metastasis, HER2 status, and metastasis situation were independent prognostic factors for the survival rate of breast cancer (all P<0.05), but other factors had no significant difference with the survival rate (Table 9). The gene discussed is SMYD3; the disease is breast carcinoma.