In the case and control groups, there were significant differences in the allele frequency (χ2 =9.356, P=0.002) and genotype frequency (χ2 =12.22, P<0.001) of EZH2 rs12670401, and C allele could increase the susceptibility to breast cancer (OR =1.255, 95% CI: 1.085–1.452, P=0.002). This evidence concerns the gene EZH2 and breast carcinoma.