Furthermore, the serum LOXL2 levels were also significantly higher in AF patients with LAD ≥ 40 mm compared with the patients with LAD < 40 mm (664.34 ± 346.50 pg/ml vs 354.90 ± 156.23 pg/ml, P<0.01, Figure 3). This evidence concerns the gene LOXL2 and atrial fibrillation.