Our model may be further used to decipher the signaling pathway from an excited neuronal membrane to the cell nucleus, addressing key regulatory events of the epigenetic machinery for other epilepsy target genes of interest, asking for communalities as shared pathomechanism of epileptogenesis, and also looking into epigenetic mechanisms of previously described gene activation (e.g. RE1 Silencing Transcription Factor/Rest [41], neurotransmitter receptors mGluR1 and 4 [42], or Ca2+ channels [43]). The gene discussed is GRM1; the disease is epilepsy.