PIK3CA and breast carcinoma: Many genetic alterations are been considered as actionable in breast cancer tumorigenesis and progression, such as mutations of TP53,KRAS, PIK3CA, and promoter methylation of breast cancer-related genes including APC, BRCA1, ER1, GSTP1, HIN1, RARβ, RASSF1 and TWIST [73–75].