With regards to other types of cancers, Wang et al. [189] reported that simvastatin induced cancer cell growth arrest and decreased nuclear YAP by interfering with protein geranylgeranylation in breast cancer, and [190] illustrated that the activation of YAP can increase cell proliferation and methotrexate/doxorubicin resistance in osteosarcoma cells. The gene discussed is YAP1; the disease is breast carcinoma.