The genomic locus of CCAT2 is highly conserved and harbors the SNP rs6983267, which was shown to be associated with risk of several cancers, such as colorectal, prostate, and thyroid [20-23] .It was previously demonstrated that CCAT2 promotes cell growth and chromosomal instability in several malignant tumors through MYC-regulated miRNAs miR-17-5p and miR-20a and other pro-metastatic targets including CDC25A.[24] Moreover, upregulation of CCAT2 can promote the proliferation and metastasis of cancer cells by enhancing the WNT pathway [25]. Here, CDC25A is linked to cancer.