Because of the existence of heterogeneity (I2=71%, p=0.008),we performed a sensitivity analysis to clarify the possible source of heterogeneity.After excluding the Zhang study[18],the heterogeneity obviously declined(I2 =49.9%, P =0.112) and the results did not change (OR=4.59, 95 % CI:2.36-8.93, P<0.001) (Sup-1,2).The results also revealed a significant difference in the LNM incidence between the two groups.Therefore, the results demonstrated that high CCAT2 expression might significantly predict a higher tendency to develop LNM in patients with cancer. This evidence concerns the gene CCAT2 and cancer.