PVT1 was a reliable diagnosis biomarkers for lung cancer, hepatobiliary cancer, renal tumor, colorectal carcinoma with the AUCs being 0.946 (0.924–0.969), 0.881 (0.849–0.913), 0.952 (0.938–0.967), 0.968 (0.934–0.999), respectively (Table 2). The gene discussed is PVT1; the disease is colorectal carcinoma.