PVT1 and cancer: The lncRNA PVT1 lies in human chromosome 8q24.21, which is a recognized cancer risk locus with the top target of copy number alterations [10], and has been reported to be dysregulated in various human tumors, such as gastric cancer, non-small cell lung cancer, colorectal cancer, esophageal cancer, pancreatic cancer, hepatocellular carcinoma [5, 11, 12].