Furthermore, research in the mechanism found PVT1 could target genes such as LASP1 [34], FOXM1 [31], RSPO1 [32], p15, p16 [33], EZH2, TSHR [33], and NOP2 [35] to promote tumor cell proliferation, migration and invasive capability in vitro. This evidence concerns the gene RSPO1 and neoplasm.