In the present meta-analysis, the pooled-AUC of 0.81 (95% CI: 0.76–0.86) and the DOR of 17.25 (95% CI: 8.43–35.27) in tissues showed that the PVT1 had relatively high efficiency to distinguish cancer; although, the pooled sensitivity and specificity were not convincing for the significant threshold effect existing [38, 39]. Here, PVT1 is linked to cancer.