Although over twenty adipokines are known; only twelve (adiponectin, leptin, IL-6, TNF-α, HGF, PAI–1, resistin, secreted frizzled-related protein 5 (SFRP-5), lipocalin 2, IL-8, apelin and visfatin) have been implicated in breast cancer [15]. This evidence concerns the gene SFRP5 and breast carcinoma.