FOXP3 and colorectal carcinoma: In addition, we found that FoxP3+ Tregs infiltrating into both stromal and intraepithelial compartments was significantly associated with early TNM stage (I+II) of CRC (OR = 2.95, 95% CI = 1.81 to 4.83, P = 0.000), whereas no significant association was observed between intraepithelial or stromal FoxP3+ Tregs and TNM stage (OR = 0.99, 95% CI = 0.33 to 3.01, P = 0.908; OR = 1.57, 95% CI = 0.84 to 2.92, P = 0.158) (Supplementary Figure 3).