As for FoxP3+ Tregs in the stromal compartment, the meta-analysis showed that there was no significant association between FoxP3+ Tregs and 1-year (OR = 1.01, 95% CI = 0.44 to 2.33, P = 0.987) or 10-year (OR = 3.18, 95% CI = 0.32 to 32.17, P = 0.326) OS; whereas FoxP3+ Tregs infiltration significantly improved 3-year (OR = 2.08, 95% CI = 1.36 to 3.17, P = 0.001) and 5-year (OR = 1.86, 95% CI = 1.31 to 2.63, P = 0.000) OS for CRC patients, with no significant heterogeneity existing among studies (Figure 5). This evidence concerns the gene FOXP3 and colorectal carcinoma.