FOXP3 and neoplasm: As for FoxP3+ Tregs density in intraepithelial compartment in tumor tissue, pooled results showed no significant association between FoxP3+ Tregs and survival, high density of FoxP3+ Tregs in intraepithelium wasn’t significantly associated with longer 1-year (OR =2.05, 95% CI = 0.72 to 5.81, P = 0.176) or 3-year OS (OR = 1.25, 95% CI = 0.65 to 2.42, P = 0.508) (Figure 4).