Most strikingly, dual manipulation of the U87MG cells with shRNA targeting HSP90AA1-IT1/miR-885-5p agomir resulted in the smallest tumor volume and longest survival rate compared with the rest of the groups, supporting overlaid effects between downregulation of HSP90AA1-IT1 and upregulation of miR-885-5p (Figure 7A, 7B, 7C). Here, HSP90AA1 is linked to neoplasm.