Moreover, decreased TOB1 expression in lung cancer (72%, 31/43), and altered TOB1 phosphorylation in lung adenocarcinoma (76%, 16/21) was shown to be an early event (stage I, 78%, 18/23), even in subjects with bronchial dysplasia (100%, 5/5) [2]. Here, TOB1 is linked to lung adenocarcinoma.