Moreover, decreased TOB1 expression in lung cancer (72%, 31/43), and altered TOB1 phosphorylation in lung adenocarcinoma (76%, 16/21) was shown to be an early event (stage I, 78%, 18/23), even in subjects with bronchial dysplasia (100%, 5/5) [2]. This evidence concerns the gene TOB1 and lung carcinoma.