In conclusion, the multifunctionality of the M7824 molecule in preclinical studies has now been shown as the ability to (a) induce anti-tumor activity in several murine models by inhibiting the binding of PD-1 to PD-L1 (Lan, manuscript submitted), (b) reverse the TGFβ1 induction of mesenchymalization of human carcinoma cells, rendering them more chemo-sensitive [38], and, as shown in this report, (c) mediate ADCC of a range of human carcinoma cells, (d) inhibit the TGFβ1 suppression of NK lysis of tumor cells, and (e) inhibit the suppressive activity of human Tregs on CD4+ T cells. This evidence concerns the gene CD274 and carcinoma.