ALB and nutritional deficiency disease: Thirdly, serum Alb was one of the most widely used markers for reflecting nutritional status and hypoproteinmia was reported as a crucial parameter of malnutrition and directly influenced prognosis of GC; low levels of Alb and pAlb levels have an impact on determinant of immune responses and malnutrition, which could impair immune system defending against GC [21, 22].