TWIST1 and breast cancer: For example, our previous studies along with others’ demonstrated that Snail expression correlates with tumor grade and nodal metastasis of invasive ductal carcinoma [14, 16]; and Slug overexpression prior to neoplastic transformation predisposes BRCA1-mutation carriers to aggressive basal-like breast cancer (BLBC) [17]; and Twist is highly expressed in invasive lobular carcinoma [18].