To test whether endogenous Slug and Twist are subject to similar regulation, we knocked down Dub3 expression in basal-like breast cancer (BLBC) cells MDA-MB157 and SUM159 and found that the protein levels of Slug and Twist, rather than mRNA levels of these two molecules, significantly decreased in these cells (Figure 1E). The gene discussed is USP17L2; the disease is breast cancer.