EGF and neoplasm: The alteration of α7nAChR accompanied by induced epidermal growth factor (EGF), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), cyclin D1, extracellular signal-regulated kinase (ERK1/2) and inhibition of mitochondrial permeability transition pore (mPTP) opening facilitates tumor promotion and progression [13-15].