The inhibition and/or depletion of RLIP76 is known to exert potent anti-proliferative effects in cancers of lung, colon, prostate, kidney, neuroblastoma and melanoma [16-18, 20, 21].The in vitro results when taken together with the ability of 2HF to inhibit the tumor progression and decrease RLIP76 protein levels in vivo triple-negative MDA-MB-231 breast cancer xenografts further provides evidence for the role of RLIP76 in mediating the effects of 2HF in breast cancer. The gene discussed is RALBP1; the disease is cancer.