Recently, several studies have identified somatic and germline BAP1 mutations in a wide-range of cancers, including mesothelioma [7–9], uveal melanoma [10–12], lung adenocarcinoma [11], renal cell carcinoma [13, 14], meningioma [11], and melanocytic neoplasms [15]. The gene discussed is BAP1; the disease is lung adenocarcinoma.