For example, Tsai et al. found that DATS attenuated hyperglycemia-induced ROS-mediated apoptosis by activating PI3K/Akt/Nrf2 signaling, which further enhanced Nrf2-mediated antioxidant enzymes in cardiomyocytes exposed to hyperglycemia [14]. The gene discussed is AKT1; the disease is Hyperglycemia.