Of note, the diminished expression of putative hub genes such as CDKN2B, CNNM4, LRRC19, and MOGAT2 might be the result of inactivation of genes through DNA methylation as their methylation was identified in colorectal, gastric, and breast cancers as well as in leukaemia [62, 69–71]. The gene discussed is CNNM4; the disease is breast cancer.