Rapamycin analogs (rapalogs) temsirolimus and everolimus have been approved by FDA for treatment of different indications including renal cell carcinoma (RCC), pancreatic neuroendocrine tumors, certain TSC-related tumors and, as part of a combination therapy, hormone-positive, HER2-negative breast cancer [5]. Here, ERBB2 is linked to renal cell carcinoma.