In conclusion, BPIS inhibits the initiation and progression of CRC by ameliorating the inflammatory microenvironment, and the presence of a signaling cascades of ROS / miR-149 / Akt / NF-κB axis for BPIS-mediated resistance to inflammation in LPS-induced HT-29 cells (Figure 7). Here, AKT1 is linked to colorectal carcinoma.