FGFR1 and neoplasm: Of 44 high FGFR1 amplified tumors, 5 cases (11.4%) only satisfied the criterion of FGFR1/ CEN8 ratio is ≥ 2.0, 7 cases (15.9%) only satisfied the criterion of an average number of FGFR1 signal per nucleus ≥6.0, and 26 cases (59.1%) only satisfied the criterion of percentage of tumor cells containing ≥ 15 FGFR1 signals or large clusters in ≥ 10% cells.