Clearly, after the patient finished radical operation, if the patient can live without recurrence or distant metastasis for more than 30 months, the FGFR1high status is important to the prognosis of the patient, indicating that high FGFR1 amplification is a delayed prognostic factor which is just as same as the prognostic value of EGFR amplification in ESCC [33]. Here, FGFR1 is linked to esophageal squamous cell carcinoma.