FGFR1 and esophageal squamous cell carcinoma: In conclusion, we demonstrated that FGFR1 amplification was an infrequent genetic alteration, and for firstly, we found high FGFR1 amplification was an independent delayed adverse prognostic factor only in stage I-II ESCC patients, suggesting that FGFR amplification may be a viable prognostic factor in these patients.