We therefore designed the current study with the two goals: (i) to examine whether LSD1 is overexpressed in other gynecologic malignancies, including multiple ovarian cancer types and uterine serous carcinoma (USC; a clinically aggressive subtype of endometrial cancer); and (ii) to investigate the effect of LSD1 inhibition on gynecologic tumor growth in relation to changes in the autophagic flux. Here, KDM1A is linked to endometrial cancer.