In GC with negative HER2 status, all sirtuins except SIRT5 and SIRT7 were associated with OS (n = 532, Table 10) and in GC with positive HER2 status, all sirtuins except SIRT4 were associated with OS (n = 344 for SIRT1-4 and 6-7; n = 202 for SIRT5). Here, SIRT4 is linked to gastric cancer.