Survival curves suggested that high expression of SIRT1 mRNA was favorable for OS (SIRT1: HR = 0.64, 95% CI = 0.54–0.76, P = 2.2E-07), high expressions of SIRT2-4 and SIRT6-7 were poor for OS (SIRT2: HR = 2.31, 95% CI = 1.87–2.87, P = 3.6E-15; SIRT3: HR = 1.99, 95% CI = 1.62–2.45, P = 2.6E-11; SIRT4: HR = 1.41, 95% CI = 1.19–1.68, P = 6.6E-05; SIRT6: HR = 2.02, 95% CI = 1.66–2.47, P = 1.7E-12; SIRT7: HR = 1.96, 95% CI = 1.63–2.35, P = 2.7E-13), and no significant association existed between SIRT5 and OS in GC (Figure 1 and Table 4). This evidence concerns the gene SIRT6 and gastric cancer.