In addition, the online database also included the first progression (FP) information of the GC patients, and the analyses results suggested that high expression of SIRT1 was associated with long FP time while high expression of SIRT2-4 and SIRT6-7 was associated with short FP time and no significant association was found between SIRT5 and FP in GC in overall (Supplementary Figure 1 and Supplementary Table 2). The gene discussed is SIRT5; the disease is gastric cancer.