Upon transfection into CRC cells, miR-1307-3p mimics led to overexpression of mature miR-1307-3p and low-expression of TYMS protein and mRNA, while miR-1307-3p inhibitors decreased the expression of mature miR-1307-3p and increased the expression of TYMS protein and mRNA (Figure 1B-1E). The gene discussed is TYMS; the disease is colorectal carcinoma.