Since the expression of TYMS mRNA and protein are inhibited by miR-1307-3p, the sensitivity of CRC cells to 5-FU is positively correlated to the expression of miR-1307-3p, indicating that the expression of miR-1307-3p might be regarded as a predictor of efficacy of 5-FU chemotherapy in colon cancer patients. The gene discussed is TYMS; the disease is colonic neoplasm.