ZNRF3 and neoplasm: Intriguingly, we also found that ZNRF3 was a direct target of miR-146a in OS cells and was negatively correlated with miR-146a expression in OS tissues; Overexpression of ZNRF3 repressed cell growth and rescued the tumor-promoting role of miR-146a via inhibition of GSK-3β/β-catenin signaling, indicating that miR-146a might promote OS tumorigenicity via targeting ZNRF3/GSK-3β/β-catenin signaling (Figure 8).