ZNRF3 and cancer: As shown in Figure 4A, under the stringent conditions including very high stringency (≥5), cancer types (≥5) and prediction software (≥3), six target genes were identified to have the potential to bind with miR-146a, of which zinc and ring finger 3 (ZNRF3) was considered as the most suitable candidate target gene of the miR-146a due to its highest binding force (Supplementary Table 3).