For example, remarkably higher expression of HOX transcript antisense RNA (HOTAIR) was detected in PTC tissues versus normal tissues [28].The expression of antisense non-coding RNA in the INK4 locus (ANRIL) was also distinctly up-regulated in thyroid cancer tissues and cells, and closely related to histological grade and status of lymph node metastasis [29]. This evidence concerns the gene CDKN2A and thyroid cancer.