HFE and central nervous system cancer: Although no association was observed between HFE expression and prostate cancer stage and progression (Figure 2C and 2D), high HFE expression was significantly associated with shorter overall survival in multiple The Cancer Genome Atlas (TCGA) cancer sets, such as breast invasive carcinoma, brain lower grade glioma, and pancreatic adenocarcinoma (Supplementary Figure 2; prostate adenocarcinoma was not calculated because of low number of deaths).